Table 2.

Summary distributions of synapse and CtBP2 puncta densities within the topographical regions of control and microgravity utricles (n = 4 each)

Parameter	Region	Gravity Condition		Percentile
			N	10	25	50	75	90	P
Synapse density, count/hair cell	Medial extrastriola	Control	48	6.94	8.19	9.72	12.36	16.02	0.0027
		Microgravity	48	5.04	5.81	6.92	8.37	9.43
	Striola	Control	70	2.26	2.76	3.61	4.54	5.52	0.85
		Microgravity	68	1.83	2.74	3.77	4.75	5.95
	Horizontal crista	Control	24	5.88	7.19	9.62	10.86	17.36	0.48
		Microgravity	24	3.76	5.74	9.01	12.06	13.30
CtBP2 puncta, count/hair cell	Medial extrastriola	Control	48	8.23	10.16	14.80	17.57	22.58	0.074
		Microgravity	48	7.08	8.10	10.74	12.62	15.21
	Striola	Control	70	4.31	6.50	8.30	9.79	11.69	0.082
		Microgravity	68	6.20	7.52	9.43	11.38	13.48
	Horizontal crista	Control	24	9.43	10.52	12.52	14.73	19.81	0.99
		Microgravity	24	8.38	9.42	12.83	18.49	21.15

Data are percentiles of synapse and CtBP2 puncta densities within the specified topographical regions of control and microgravity utricles (n = 4 each). N value reflects the total number of measurements included in the distribution, including those made by 2 “observers” on the same specimens. Specimens included, in general, 3 subregions from each area (2 for medial extrastriola, 3 from striola, and 1 from the horizontal crista) within the topographical regions specified. As discussed in methods, appropriate consideration of nonindependent measures was a critical component of implementation of the linear mixed-effects analytical model.