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α2-adrenoceptor binding in mPFC of rats exposed to acute or chronic treatment with WIN 55,212-2. There was no change in the α2-adrenoceptor mRNA expression in the mPFC following acute or repeated administration of WIN 55,212-2 compared to control. However, following a period of abstinence from chronic WIN 55,212-2 exposure, there was a significant increase in α2-adrenoceptor mRNA binding in the mPFC. *P 0.05 vs WIN 55,212-2. Bottom panels show boxed region at a higher magnification.
