Fig. 1.

Surfactant dose-dependently inhibits BzATP-mediated release of IL-1β. Different concentrations of the natural surfactant preparation, Alveofact^® (A), and the synthetic surfactant, Venticute^® (B), were added to LPS-primed U937 cells together with BzATP. IL-1β levels were measured 30 min thereafter in cell culture supernatants. Nicotine was included as a known inhibitor of BzATP-dependent IL-1β release. A Kruskal-Wallis test was followed by Mann-Whitney rank-sum test; data are presented as individual data points; bars represent median; whiskers represent percentiles 25 and 75.