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. 2017 Apr 12;58(6):1080–1090. doi: 10.1194/jlr.M072587

Fig. 4.

Fig. 4.

DHA metabolites by LOX blocked NLRP3 inflammasome formation and activation in podocytes of hyperhomocysteinemic mice. A: Representative images and summarized data of the colocalization between NLRP3 (green) and ASC (red) in glomeruli from mice with different genotypes and treatments (n = 6). B: Representative images and summarized data of the colocalization between NLRP3 (green) and caspase-1 (red) in glomeruli from mice with different genotypes and treatments (n = 6). C: Immunohistochemical staining of IL-1β production in glomeruli from mice with different genotypes and treatments (n = 5). D: Immunohistochemical staining of IL-18 production in glomeruli from mice with different genotypes and treatments (n = 5). E: IL-1β production in isolated glomeruli from WT mice with different treatments (n = 4). F: IL-18 production in isolated glomeruli from WT mice with different treatments (n = 4). *P < 0.05 versus WT-ND-Vehl group, #P < 0.05 versus WT-FF-Vehl group, $P < 0.05 versus WT-FF-DHA group. Vehl, vehicle.