Fig. 3.

Feeding Angptl4^−/− mice a diet rich in trans or saturated FAs results in Touton giant cells in MLNs. A: Representative photograph after H&E staining showing enlarged MLN in Angptl4^−/− mice fed the saturated or trans fat diet, but not the cis unsaturated fat diet. B: Lower magnification (×100) images showing the relative abundance of Touton giant (foam) cells in the MLN of Angptl4^−/− mice fed the saturated or trans fat diet, but not the cis unsaturated fat diet. C: Higher magnification (×200; insert ×400) images of giant cells in MLNs of the Angptl4^−/− mice fed the trans or saturated fat diet. Black arrows indicate giant cells.