TABLE 4.

Independent predictors of parameters related to glucose and lipid metabolism in biopsy-proven NAFLD subjects and matched controls on multivariate logistic regression analysis (n = 120)

Outcome Variable	Independent Predictor	OR (95% CI)	P
OGTT-related parameters of glucose homeostasis
OGIS	IAUC adiponectin	1.50 (1.15–2.51)	0.001
Hepatic IR	IAUC adiponectin	0.54 (0.16–0.86)	0.001
	IAUC resistin	1.58 (1.12–2.63)	0.006
Adipose tissue IR	PNPLA3	1.52 (1.06–2.76)	0.008
	IAUC VLDL1-Chol	1.45 (1.05–2.59)	0.002
Muscle IS	IAUC adiponectin	1.47 (1.07–2.46)	0.011
	IAUC GIP	0.49 (0.18–0.91)	0.012
IGI	TM6SF2	0.49 (0.04–0.83)	0.009
	IAUC adiponectin	1.49 (1.04–2.50)	0.004
DI	TM6SF2	0.51 (0.16–0.86)	0.001
	IAUC adiponectin	1.49 (1.12–2.55)	0.009
CGI	TM6SF2	0.46 (0.11–0.81)	0.001
	IAUC adiponectin	1.68 (1.04–2.50)	0.003
AI	TM6SF2	0.43 (0.10–0.70)	0.001
	IAUC adiponectin	1.79 (1.23–2.84)	0.002
Incretin effect	TM6SF2	0.45 (0.11–0.80)	0.009
	IAUC GIP	0.51 (0.16–0.86)	0.007
OFTT parameters
IAUC Tgs	IAUC adiponectin	0.50 (0.14–0.87)	0.003
	TM6SF2	0.47 (0.02–0.82)	0.001
IAUC VLDL1-Tg	IAUC adiponectin	0.49 (0.13–0.84)	0.001
	TM6SF2	0.43 (0.08–0.78)	0.0009
IAUC VLDL1-Chol	TM6SF2	1.69 (1.11–2.81)	0.00002
IAUC VLDL2-Chol	TM6SF2	1.55 (1.15–2.60)	0.0009
IAUC VLDL1-apoB100	TM6SF2	0.49 (0.13 –0.83)	0.002
IAUC VLDL2-apoB100	TM6SF2	0.45 (0.10–0.81)	0.004
IAUC VLDL1-apoB48	TM6SF2	0.44 (0.02–0.80)	0.0001
IAUC VLDL2-apoB48	TM6SF2	0.51 (0.06–0.91)	0.023
IAUC LDL-C	TM6SF2	0.50 (0.15–0.85)	0.003
	Fasting LDL-C	1.91 (0.36–3.11)	0.0008
IAUC LDL conjugated dienes	IAUC VLDL1-Tg	1.89 (1.23–2.95)	0.0001
IAUC HDL-C	IAUC VLDL1-Tg	0.52 (0.17–0.87)	0.009
IAUC GIP	TM6SF2	1.88 (1.21–3.01)	0.001
IAUC resistin	TM6SF2	1.58 (1.13–2.92)	0.012

IS, insulin sensitivity.