TABLE 3.
Statistical analyses of effects of pretreatments on self-administration of cocaine as shown in Fig. 3
Comparisons were made in the rates of responses on the active lever maintained during each corresponding component in six subjects using a two-way repeated-measures ANOVA followed by post-hoc Bonferroni t tests. The post hoc results are shown only if effects were statistically significant. The Δ values, in responses/second, were calculated as a subtraction of response rates maintained by cocaine after pretreatment with the BZT analog from those obtained after saline pretreatment.
| Pretreatment | Cocaine Unit Dose | Pretreatment Dose | Interaction | Post-Hoc Tests |
|---|---|---|---|---|
| AHN 1-055 | F4,60 = 5.91; P = 0.003 | F3,60 = 7.56; P = 0.003 | F12,60 = 8.57; P < 0.001 | 3.2 mg/kg (i.p.) at EXT, t = 3.08, P = 0.009 (Δ = +0.080) |
| 3.2 mg/kg (i.p.) at 0.032 mg/kg per inj (i.v.), t = 4.41, P < 0.001 (Δ = +0.114) | ||||
| 3.2 mg/kg (i.p.) at 0.10 mg/kg per inj (i.v.), t = 3.54, P = 0.002 (Δ = −0.092) | ||||
| 3.2 mg/kg (i.p.) at 0.32 mg/kg per inj (i.v.), t = 6.08, P < 0.001 (Δ = −0.157) | ||||
| 10 mg/kg (i.p.) at 0.10 mg/kg per inj (i.v.), t = 4.64, P < 0.001 (Δ = −0.120) | ||||
| 10 mg/kg (i.p.) at 0.32 mg/kg per inj (i.v.), t = 5.85, P < 0.001 (Δ = −0.151) | ||||
| AHN 2 -005 | F4,60 = 13.7; P < 0.001 | F3,60 = 14.4; P < 0.001 | F12,60 = 11.5; P < 0.001 | 1.0 mg/kg (i.p.) at 0.10 mg/kg per inj (i.v.), t = 3.91, P = 0.001 (Δ = −0.087) |
| 3.2 mg/kg (i.p.) at 0.10 mg/kg per inj (i.v.), t = 7.10, P < 0.001 (Δ = −0.158) | ||||
| 3.2 mg/kg (i.p.) at 0.32 mg/kg inj (i.v.), t = 7.14, P < 0.001 (Δ = −0.159) | ||||
| 10 mg/kg (i.p.) at 0.10 mg/kg per inj (i.v.), t = 7.22, P < 0.001 (Δ = −0.161) | ||||
| 10 mg/kg (i.p.) at 0.32 mg/kg/inj (i.v.), t = 9.37, P < 0.001 (Δ = −0.208) | ||||
| JHW 007 | F4,60 = 7.31; P < 0.001 | F3,60 = 8.52; P = 0.002 | F12,60 = 7.01; P < 0.001 | 3.2 mg/kg (i.p.) at 0.10 mg/kg/inj (i.v.), t = 4.87, P < 0.001 (Δ = −0.127) |
| 3.2 mg/kg (i.p.) at 0.32 mg/kg per inj (i.v.), t = 5.23, P < 0.001 (Δ = −0.137) | ||||
| 10 mg/kg (i.p.) at 0.10 mg/kg per inj (i.v.), t = 5.08, P < 0.001 (Δ = −0.133) | ||||
| 10 mg/kg (i.p.) at 0.32 mg/kg per inj (i.v.), t = 6.91, P < 0.001 (Δ = −0.180) |
Inj, injection.