TABLE 1.
ED50 values in mg/kg (95% confidence intervals) for methylphenidate, SKF82958, and quinpirole in the assays of acid-depressed ICSS and acid-stimulated stretching
“Inactive” indicates a failure to produce at least 50% blockade in acid-depressed ICSS. The D2-preferring agonist sumanirole and the D3-preferring agonist pramipexole were inactive in acid-depressed ICSS and were not tested in acid-stimulated stretching.
| Acid-Depressed ICSS | Acid-Stimulated Stretching | |
|---|---|---|
| Drug | ED50 (95% CI) | ED50 (95% CI) |
| Methylphenidate | 0.20 (0.13—0.30) | 1.02 (0.62—1.66) |
| SKF82958 | 0.020 (0.0067—0.060) | 0.035 (0.020—0.060) |
| Quinpirole | Inactive | 0.0043 (0.0018—0.010) |
95% CI, 95% confidence interval.