Table 2.
Demographic, Clinical, and Laboratory Features of Ph-Negative MPNs.
| Characteristics | PV | ET | PMF* | MPN-U* |
|---|---|---|---|---|
| Number of patient, N (%) | 38.0 (38.0%) | 55.0 (55.0%) | 4.0 (4.0%) | 3.0 (3.0%) |
| Frequency of JAK2 (V617F) positive, N (%) | 36.0 (94.7%) | 41.0 (74.5%) | 1.0 (25.0%) | 4.0 (100.0%) |
| Frequency of CALR exon 9 positive, N (%) | N/A | 5.0 (35.7%)* | 1.0 (33.3%)* | N/A |
| Frequency of MPL (W515K/L) positive, N (%) | N/A | 0.0 | 0.0 | N/A |
| Age (years) Mean (±SD) | 62.9 (±2.2) | 62.2 (±2.5) | 65.0 (47.0-77.8) | 76.0(73.0-82.0) |
| Male (% of total) | 23.0 (60.5%) | 23.0 (41.8%) | 2.0(50.0%) | 2.0 (66.7%) |
| WBC count (x103/µL) Mean (±SD) | 14.9 (±1.1) | 11.7 (±0.8) | 13.6 (5.2-21.1) | 57.6 (33.0-101.9) |
| Hb (g/dL) Mean (±SD) | 17.6 (±0.5) | 12.3 (±0.3) | 9.8 (6.2-12.0) | 10.6 (7.0-11.5) |
| Hct (%) Mean (±SD) | 55.1 (±1.5) | 37.7 (±0.8) | 31.2 (19.2-36.8) | 33.9 (22.4-35.4) |
| Platelet count (x103/µL) Mean (±SD) | 471.8 (±35.5) | 793.3 (±37.6) | 471.5 (147.0-814.0) | 338.0 (105.0-453.0) |
| JAK2 (V617F) allele burden (%) Mean (±SD) | 63.0 (±4.5) | 25.1 (±2.9) | 2.5 (0.25-5.3) | 50.0 (46.0-97.0) |
| Thrombotic events, N (%) | 7.0 (18.4%) | 15.0 (27.3%) | 2.0 (50.0%) | 2.0 (66.7%) |
| Bleeding events, N (%) | 1.0 (2.6%) | 5.0 (9.1%) | 1.0 (25.0%) | 0.0 |
| Splenomegaly, N (%) | 2 (5.3%) | 2.0 (3.6%) | 3.0 (75.0%) | 0.0 |
| History of MF transformation, N (%) | 0.0 | 4.0 (7.3%) | 4.0 (100.0%) | 0.0 |
N/A, Not analyzed;
*
Data of PMF and MPN-U group were revealed by Median (Range) values