Table 1.
IGFs, IGFBPs and PAPP-A Level (ng/mg of Protein) in Primary Tumor and Ascites in Patients with Early and Advanced Ovarian Cancer, Me (25-75%)
| Sample type | Parameters | ||||
|---|---|---|---|---|---|
| IGF-I | IGF-II | IGFBP-3 | IGFBP-4 | PAPP-A | |
| Primary tumor (IB, C Stage), n=15 | 0.1 (0.1-0.4) | 3.4 (2.0-3.6) | 17.9 (16.2-24.4) | 6.0 (3.6-12.4) | 0.4 (0.01-0.4) |
| Primary tumor (IIIC-IV Stage), n=59 | 0.1 (0.060-0.305) | 5.6 (3.28-8.49) | 5.9 (0.90-8.10) | 3.6 (0.6-5.6) | 0.3 (0.09-0.32) |
| Ascites (IIIC-IV Stage), n=53 | 2.5 (0.9-2.7) P2,3<0.05 | 115.0 (89.0-183.0) P1,2<0.05 P2,3<0.05 | 190.0 (140.0-266.0) P1,2<0.05 P2,3<0.05 | 62.3 (51.4-77.8) P2,3<0.05 | 0.2 (0.05-0.42) |
Note, 1,2 – changes between protein levels in tumor samples in early and advanced ovarian cancer; 2,3 – changes between protein levels in primary tumor and ascites