Figure 4.

Gimatecan Administration Did Not Severely Affect Body Weights.

Four types of HCC cell lines, Huh-1, Hep G2, HCCLM3, and PLCPRF5 were inoculated subcutaneously on the right side of the mouse back, respectively. In each tumor-bearing model mice were divided into four groups (n = 10 for each group) and orally administered with 0.8 mg/kg (×), 0.4 mg/kg (◆), and 0.1 mg/kg (●) gimatecan every four days for a total of four times, respectively. The control mice were administered with 10 µl 10%DMSO/g (●). Mouse body weights were measured twice weekly and at study termination.