Table 1.
Model | Treatment | TVI(%) | P valuea |
---|---|---|---|
Huh-1 | Vehicle control | -- | -- |
Gimatecan (0.8 mg/kg) | 62 | <0.001 | |
Gimatecan (0.4 mg/kg) | 30 | 0.002 | |
Gimatecan (0.1 mg/kg) | 14 | 0.140 | |
HepG2 | Vehicle control | -- | -- |
Gimatecan (0.8 mg/kg) | 95 | <0.001 | |
Gimatecan (0.4 mg/kg) | 74 | <0.001 | |
Gimatecan (0.1 mg/kg) | 24 | 0.101 | |
HCCLM3 | Vehicle control | -- | -- |
Gimatecan(0.8 mg/kg) | 88 | <0.001 | |
Gimatecan(0.4 mg/kg) | 68 | <0.001 | |
Gimatecan(0.1 mg/kg) | 34 | 0.014 | |
PLC/PRF/5 | Vehicle control | -- | -- |
Gimatecan(0.8 mg/kg) | 71 | <0.001 | |
Gimatecan(0.4 mg/kg) | 47 | <0.001 | |
Gimatecan(0.1 mg/kg) | 4 | 0.718 |