Table 2. Effect of baseline factors on immune reconstitution.
| Univariate Analysis | Multivariable Analysis | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Slope | 95%CI | P-value | Slope | 95%CI | P-value | |
| log(ALC) n =324 | ||||||
|
| ||||||
| Age (10-year increment) | 0.04 | -0.02 , 0.09 | .195 | |||
| Sex (Male) | 0.11 | -0.09 , 0.31 | .275 | |||
| ATG use | -0.38 | -0.61 , -0.16 | .001 | |||
| HLA Identical | 0.43 | 0.22 , 0.65 | <.001 | 0.43 | 0.22 , 0.65 | <.001 |
| Regimen (chemo only) | 0.14 | -0.14 , 0.43 | .332 | |||
| 1st Remission | -0.02 | -0.22 , 0.19 | .865 | |||
| Diagnosis (ALL) | -0.19 | -0.41 , 0.04 | .103 | |||
| PBSC only | 0.16 | -0.04, 0.36 | .111 | |||
| Donor Sex (Male) | 0.17 | -0.02, 0.37 | .079 | |||
|
| ||||||
| log(CD4), n = 315 | ||||||
|
| ||||||
| Age (10-year increment) | -0.01 | -0.08 , 0.06 | .698 | |||
| Sex (Male) | 0.28 | 0.03 , 0.52 | .027 | |||
| ATG use | -0.66 | -0.94 , -0.39 | <.001 | -0.66 | -0.94 , -0.39 | <.001 |
| HLA Identical | 0.43 | 0.15 , 0.71 | .003 | |||
| Regimen (chemo only) | 0.07 | -0.30 , 0.44 | .698 | |||
| 1st Remission | 0.25 | 0 , 0.51 | .052 | |||
| Diagnosis (ALL) | -0.07 | -0.35 , 0.21 | .622 | |||
| PBSC only | 0.14 | -0.11, 0.38 | .275 | |||
| Donor Sex (Male) | -0.05 | -0.30, 0.19 | .666 | |||
|
| ||||||
| log(CD8), n = 314 | ||||||
|
| ||||||
| Age (10-year increment) | -0.01 | -0.10 , 0.07 | .746 | |||
| Sex (Male) | 0.27 | -0.04 , 0.58 | .085 | |||
| ATG use | -0.26 | -0.62 , 0.09 | .149 | |||
| HLA Identical | 0.50 | 0.15 , 0.85 | .006 | 0.50 | 0.15 , 0.85 | .006 |
| Regimen (chemo only) | -0.08 | -0.54 , 0.39 | .745 | |||
| 1st Remission | -0.10 | -0.43 , 0.22 | .527 | |||
| Diagnosis (ALL) | -0.03 | -0.38 , 0.32 | .854 | |||
| PBSC only | -0.40 | -0.70, -0.09 | .011 | |||
| Donor Sex (Male) | -0.24 | -0.54, 0.07 | .132 | |||
|
| ||||||
| log(NK), n = 314 | ||||||
|
| ||||||
| Age (10-year increment) | 0.05 | 0 , 0.09 | .059 | |||
| Sex (Male) | -0.06 | -0.22 , 0.11 | .508 | |||
| ATG use | -0.23 | -0.42 , -0.04 | .019 | |||
| HLA Identical | 0.28 | 0.08 , 0.47 | .005 | 0.28 | 0.08 , 0.47 | .005 |
| Regimen (chemo only) | 0.17 | -0.08 , 0.42 | .190 | |||
| 1st Remission | 0.04 | -0.13 , 0.22 | .640 | |||
| Diagnosis (ALL) | -0.15 | -0.34 , 0.04 | .118 | |||
| PBSC only | 0.16 | 0, 0.33 | .055 | |||
| Donor Sex (Male) | 0.14 | -0.02, 0.3 | .097 | |||
|
| ||||||
| log(CD45), n= 187 | ||||||
|
| ||||||
| Age (10-year increment) | -0.10 | -0.20 , 0.01 | .066 | |||
| Sex (Male) | 0.23 | -0.17 , 0.63 | .266 | |||
| ATG use | -0.86 | -1.30 , -0.42 | <.001 | -0.86 | -1.30 , -0.42 | <.001 |
| HLA Identical | 0.38 | -0.03 , 0.80 | .072 | |||
| Regimen (chemo only) | -0.19 | -0.72 , 0.35 | .488 | |||
| 1st Remission | 0.12 | -0.30 , 0.54 | .585 | |||
| Diagnosis (ALL) | 0.18 | -0.25 , 0.60 | .419 | |||
| PBSC only | 0.08 | -0.32, 0.48 | .699 | |||
| Donor Sex (Male) | 0.08 | -0.32, 0.47 | .711 | |||
|
| ||||||
| log(PHA), n =258 | ||||||
|
| ||||||
| Age (10-year increment) | -0.17 | -0.26 , -0.08 | <.001 | -0.16 | -0.25 , -0.07 | .001 |
| Sex (Male) | 0.00 | -0.34 , 0.33 | .980 | |||
| ATG use | -0.58 | -0.95 , -0.21 | .002 | -0.53 | -0.89 , -0.16 | .005 |
| HLA Identical | 0.32 | -0.06 , 0.71 | .100 | |||
| Regimen (chemo only) | 0.04 | -0.45 , 0.52 | .883 | |||
| 1st Remission | 0.26 | -0.09 , 0.60 | .144 | |||
| Diagnosis (ALL) | 0.20 | -0.17 , 0.57 | .285 | |||
| PBSC only | 0.02 | -0.31, 0.35 | .917 | |||
| Donor Sex (Male) | 0.07 | -0.26, 0.40 | .678 | |||
a
The factors without estimates and p value were not significant in multivariable analysis.
ALC: absolute lymphocyte count; ATG: antithymocyte globulin; ALL: acute lymphoblastic leukemia; PBSC: peripheral blood stem cells; NK: natural killer; PHA: phytohemagglutinin.