Fig. 1.

Illustration of imaging pipeline for whole-brain atrophy rates and ventricular enlargement over time. (A) Whole-brain atrophy as quantified by SIENA. Each image shows the changes between baseline and 18 months for each representative subject. Red indicates brain volume increase, whereas blue represents atrophy. (B) VIENA was used to calculate ventricular percentage changes between baseline and 18 months after a ventricular mask (red pixels) were registered to each individual MRI to identify ventricular edge displacements. Abbreviation: VIENA, ventricular enlargement. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)