Table 1.
Characteristics of 240 hepatitis C virus (HCV) genotype (GT)-1 patients at the start of treatment.
| Characteristics | All (n = 240) | Treatment-Naïve (n = 138) | Treatment-Experienced (n = 102) | p-Values 1 |
|---|---|---|---|---|
| Age (years) | 65.8 ± 11.6 | 67.5 ± 11.3 | 63.5 ± 11.6 | 0.00787 |
| Gender (male/female) | 110/130 | 59/79 | 51/51 | 0.328 |
| Interferon (naive/experienced) | 138/102 | 138/0 | 0/102 | N.A. |
| HCV GT (1a/1b/1) | 6/206/28 | 4/120/14 | 2/86/14 | 0.994 |
| HCV RNA (L/H) | 22/218 | 20/118 | 2/100 | 0.00194 |
| Body weight (kg) | 56.9 ± 10.2 | 55.9 ± 11.1 | 58.2 ± 8.8 | 0.0851 |
| Body length (cm) | 160 ± 9.5 | 160 ± 9.3 | 161 ± 9.7 | 0.420 |
| History of HCC +/− | 43/197 | 26/112 | 17/85 | 0.792 |
| Chronic hepatitis/cirrhosis | 153/87 | 88/50 | 65/37 | 0.897 |
| Liver stiffness (kPa) | 11.4 ± 12.7 | 10.8 ± 12.4 | 12.2 ± 13.1 | 0.399 |
| AST (IU/L) | 51.4 ± 32.0 | 48.1 ± 24.2 | 55.9 ± 39.9 | 0.0617 |
| ALT (IU/L) | 46.9 ± 40.2 | 41.6 ± 26.9 | 54.0 ± 52.5 | 0.0179 |
| Hemoglobin (g/dL) | 13.4 ± 1.6 | 13.4 ± 1.5 | 13.5 ± 1.6 | 0.620 |
| Platelets (×104/μL) | 15.3 ± 6.8 | 15.7 ± 7.5 | 14.9 ± 5.7 | 0.368 |
| eGFR (mL/min/1.73 m2) | 74.4 ± 17.9 | 73.2 ± 16.7 | 76.3 ± 19.6 | 0.188 |
Data are expressed as the mean ± standard deviation (SD). HCC, hepatocellular carcinoma; HCV RNA: L, <5.0 LIU/mL and H, ≥5.0 LIU/mL; AST, aspartate aminotransferase; ALT, alanine aminotransferase; eGFR, estimated glomerular filtration rates; N.A., not available. 1 p-values, treatment-naïve versus treatment-experienced groups.