Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 27;18(5):920. doi: 10.3390/ijms18050920

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The focal adhesion kinase (FAK) signaling pathway regulates YKL-40-induced increases in IL-18 expression. (A,B) MG-63 cells were pretreated with a FAK inhibitor (10 μM) or transfected with FAK siRNA for 24 h, then stimulated with YKL-40 for 24 h. IL-18 expression was examined using qPCR and ELISA assays (n = 4 per group). (C,D) CM was collected and applied to EPCs. Capillary-like structure formation and cell migration of EPCs was examined by tube formation and Transwell assay (n = 5 per group). (E) MG-63 cells were treated with YKL-40 for indicated time intervals, and FAK phosphorylation was examined by Western blotting. FAK phosphorylation in each independent experiment was quantified by densitometry in right panel (n = 3 per group). Results are expressed as the mean ± S.E. * p < 0.05 compared with control. ^# p < 0.05 compared with the YKL-40-treated group.