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. 2017 Apr 28;18(5):924. doi: 10.3390/ijms18050924

Figure 2.

Figure 2

Preclinical test results showing ex vivo and in vivo imaging and photothermal effect measurement of indocyanine green (ICG)-micelle with or without doxorubicin (DOX) drug loaded nanoparticles. (A) Ex vivo imaging of ICG from free ICG/DOX and ICG/DOX-micelles in heart, liver, spleen, lung, kidney, and tumor of the mice at 24 h post-injection at the dose of 7.5 mg/kg ICG/DOX, respectively; (B) In vivo near-infrared fluorescence (NIRF) imaging of the mice bearing A549 tumor injected with I/D-micelles at the dose of 7.5 mg/kg ICG/DOX at 1, 2, 4, and 6 days post-injection, respectively; (C) Tumor growth inhibition profiles of the mice bearing A549 tumor injected with various formulations; (D) Photographic view of tumors extracted from the mice bearing A549 tumor at the end of the experiment. Figure adapted from [25].