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. 2017 Apr 30;18(5):935. doi: 10.3390/ijms18050935

Figure 3.

Figure 3

Nobiletin inhibited VEGF-dependent Src/FAK/STAT3 signaling and angiogenic factors. (A) Western blotting analysis in MCF-7 cells showing a downregulation of Src/FAK/STAT3 signaling after treatment with 200 μM nobiletin, 25 μM axitinib, and pre-treatment with 25 μg/mL recombinant human VEGF followed by treatment with nobiletin; (B) Concentration-dependent inhibition of Src/FAK/STAT3 signaling by nobiletin using western blotting analysis; (C) RT-PCR analysis showing the inhibition of angiogenic factors after treatment with nobiletin for 24 h.