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. 2017 Apr 30;18(5):935. doi: 10.3390/ijms18050935

Figure 6.

Figure 6

Nobiletin inhibited migration, cell invasion abilities, and MMP expression. (A) Wound-healing assay assessing the migration inhibition ability of nobiletin in MCF-7 cells for 24 h. Scale bars: 50 μm; (B) Relative inhibition of migration by nobiletin. Statistical analysis was conducted using ANOVA (*** p < 0.001); (C) Matrigel invasion assay showing the invasion inhibition by nobiletin in MCF-7 cells for 24 h. Scale bars: 100 μm; (D) Relative invasion of MCF-7 cells after treatment with nobiletin. Statistical analysis was performed using ANOVA (** p < 0.01, *** p < 0.001); (E) RT-PCR analysis of MMP2, MMP3, and MMP9 after treatment with nobiletin in MCF-7 cells for 24 h; (F) Western blotting analysis showing the inhibition MMP2, MMP3, and MMP9 by nobiletin in MCF-7 cells for 24 h.