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. 2017 Apr 29;18(5):942. doi: 10.3390/ijms18050942

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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RE-CE alleviates ionizing radiation (IR)-induced myelosuppression and promotes myeloid skewing recovery in irradiated mice. Mice were sham-irradiated as the control or irradiated with 4 Gy TBI after receiving the vehicle or RE-CE treatment as described in the Materials and Methods. The number of white blood cells (WBCs) (A), lymphocyte percentage (LY%) (B), and neutrophil percentage (NE%) (C) in peripheral blood were quantified on the 14th day after exposure to TBI. The percentage of B cells (D), T cells (E), and myeloid cells (F) in peripheral blood were analyzed by Fluorescence-Activated Cell Sorting (FACS) on the 14th day after exposure to TBI. RE-CE treatment significantly elevated WBC counts, LY%, B cell percentage, T cell percentage, and reduced NE% and myeloid cell percentage. All data are presented as means ± SEM (n = 5).

RE-CE alleviates ionizing radiation (IR)-induced myelosuppression and promotes myeloid skewing recovery in irradiated mice. Mice were sham-irradiated as the control or irradiated with 4 Gy TBI after receiving the vehicle or RE-CE treatment as described in the Materials and Methods. The number of white blood cells (WBCs) (A), lymphocyte percentage (LY%) (B), and neutrophil percentage (NE%) (C) in peripheral blood were quantified on the 14th day after exposure to TBI. The percentage of B cells (D), T cells (E), and myeloid cells (F) in peripheral blood were analyzed by Fluorescence-Activated Cell Sorting (FACS) on the 14th day after exposure to TBI. RE-CE treatment significantly elevated WBC counts, LY%, B cell percentage, T cell percentage, and reduced NE% and myeloid cell percentage. All data are presented as means ± SEM (n = 5).