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. 2017 Apr 29;18(5):942. doi: 10.3390/ijms18050942

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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RE-CE improves colony forming and engraftment abilities of HSPCs in irradiated mice. Mice were daily treated with the vehicle or RE-CE as described in the Materials and Methods. (A) The number of colonies of granulocyte macrophage cells (CFU-GM) per 10⁵ bone marrow cells (BMCs); (B) The number of spleen colony-forming units (CFU-S) on the 14th day after exposure to TBI; (C) Representative H&E stained femurs (×40) on the 14th day after exposure to TBI; (D) Donor cell engraftment in the peripheral blood of recipients 4 months after competitive bone marrow transplantation. RE-CE treatment significantly increased the number of CFU-GM and CFU-S, and promoted HSPCs colony forming and donor cell engraftment in irradiated mice. The data are presented as means ± SEM (n = 5 in panel A and B, n = 10 in panel C).

RE-CE improves colony forming and engraftment abilities of HSPCs in irradiated mice. Mice were daily treated with the vehicle or RE-CE as described in the Materials and Methods. (A) The number of colonies of granulocyte macrophage cells (CFU-GM) per 10⁵ bone marrow cells (BMCs); (B) The number of spleen colony-forming units (CFU-S) on the 14th day after exposure to TBI; (C) Representative H&E stained femurs (×40) on the 14th day after exposure to TBI; (D) Donor cell engraftment in the peripheral blood of recipients 4 months after competitive bone marrow transplantation. RE-CE treatment significantly increased the number of CFU-GM and CFU-S, and promoted HSPCs colony forming and donor cell engraftment in irradiated mice. The data are presented as means ± SEM (n = 5 in panel A and B, n = 10 in panel C).