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. 2017 May 1;18(5):952. doi: 10.3390/ijms18050952

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Inactivation of human liver microsomal formation of N-desethylamodiaquine from amodiaquine by various fargesin concentrations; (B) The relationship between the observed k (k_obs) and fargesin concentration for the estimation of the K_i and k_inact values of CYP2C8-catalyzed amodiaquine N-deethylation; (C) Inactivation of human liver microsomal formation of 4′-hydroxy-[S]-mephenytoin from [S]-mephenytoin by various fargesin concentrations; (D) The relationship between k_obs and fargesin concentration for the estimation of the K_i and k_inact values of CYP2C19-catalyzed [S]-mephenytoin 4′-hydroxylation; (E) Inactivation of human liver microsomal formation of 1′-hydroxymidazolam from midazolam by various fargesin concentrations; and (F) The relationship between the k_obs and fargesin concentration for the estimation of the K_i and k_inact values of CYP3A4-catalyzed midazolam 1′-hydroxylation.