Table 3.
TE-mediated chromosomal structure defects in human cancers.
| Locus of Genes | TE(s) | Chromosomal Defects | Associated Cancer | References |
|---|---|---|---|---|
| BCR-ABL | Alu | Chromosomal translocation | CML | [126] |
| BRCA1 | Alu | Chromosomal deletion, duplication, insertion | Breast, ovarian cancer | [127] |
| BRCA2 | Alu | Chromosomal deletion, duplication, insertion | Breast, ovarian cancer | [12,128] |
| CAD | Alu | Chromosomal deletion | Hepatocellular carcinoma | [122] |
| CDH1 | Alu | Chromosomal deletion | Diffuse gastric cancer | [129] |
| EWSR1-ETV | Alu, LINE1 | Chromosomal translocation | Ewing sarcoma | [28] |
| MAD1L1 | LTR | Chromosomal instability | Breast cancer | [8,130] |
| MLL1 | Alu | Chromosomal duplication | AML | [131] |
| MYB | Alu | Chromosomal duplication | T-ALL | [132] |
| VHL | Alu | Chromosomal deletion | von Hippel Lindau disease | [133] |
| WT1 | LINE1 | Chromosomal translocation | Sarcoma | [28] |