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. 2017 May 6;18(5):999. doi: 10.3390/ijms18050999

Figure 1.

Figure 1

(a) Family 33: pedigree of index case (ID 409) carrier intronic variant c.457+33_+34insGTGT in exon 2 of MSH6 gene; (b) Family 26: pedigree of the index case (ID 210) carrier missense variant c.1395 A>T in exon 4 of the MSH6 gene; (c) Family 102: pedigree of the index case (ID 1454) carrier in the frame variant c.2049_2050insAGT in exon 5 of the MSH6 gene. Symbols and abbreviations used are denoted as follows: arrow, index case; black symbol, cancers or colon adenomas associated with LS; Co, colon cancer; Ad, adenoma with moderate dysplasia; Hp, hyperplastic polyps; Bla, bladder cancer; Pro, prostate cancer. The number next to the diagnosis denotes age at onset. * Denotes family members are carriers of a specific variant.