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. 2017 May 6;18(5):999. doi: 10.3390/ijms18050999

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Family 21 pedigree of the index case (ID 105) carrier of novel frameshift variant, c. 3296_97delTT in exon 5 of the MSH6 gene; (b) Family pedigree of the index case (ID 103) carrier of known frameshift variant c. 3261dupC in exon 5 of the MSH6 gene. Symbols and abbreviations used are denoted as follows: arrows, index case; black symbol, cancers or colon adenomas associated with LS; Co, colon cancer; CoR, colorectal cancer; Ga, gastric cancer; End, endometrial cancer; Ad, adenoma with severe dysplasia; HP, hyperplastic polyps. Numbers next to the diagnosis denote age at onset; Analysed members that were not carried of mutation.

Inline graphic — (a) Family 21 pedigree of the index case (ID 105) carrier of novel frameshift variant, c. 3296_97delTT in exon 5 of the MSH6 gene; (b) Family pedigree of the index case (ID 103) carrier of known frameshift variant c. 3261dupC in exon 5 of the MSH6 gene. Symbols and abbreviations used are denoted as follows: arrows, index case; black symbol, cancers or colon adenomas associated with LS; Co, colon cancer; CoR, colorectal cancer; Ga, gastric cancer; End, endometrial cancer; Ad, adenoma with severe dysplasia; HP, hyperplastic polyps. Numbers next to the diagnosis denote age at onset; Analysed members that were not carried of mutation.