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MSH6, MSH2 and MLH1 immunohistochemistry (IHC) results in the colon tumor section of the index Case 103 carrier of the c.3261dup variant in MSH6 exon 5. (a) Absence of MSH6 protein in the tumor cells; (b) normal IHC for MSH2 protein in the tumor cells; (c) normal IHC for MLH1 protein in the tumor cells. Arrows point to IHC− tumor cells; filled arrow heads point to IHC+ tumor cells; open arrow heads point to blue nuclear staining of lymphocytes (positive internal control).
