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. 2017 May 7;18(5):1005. doi: 10.3390/ijms18051005

Figure 4.

Figure 4

Image of the ALU clusters labelled by combinatorial oligonucleotide fluorescence in situ hybridization (COMBO-FISH) probes (red) and heterochromatin labelled by H3K9me3 antibodies (green). (A) Density image: Pixelsize = 10 nm/pixel, radius = 1000 nm, Gaussian filter σ = 50 nm; (B) Zoom of the marked region indicating the closed point patterns; (C) and (D) binary depiction of the same region shown in (B); (C) Every point corresponds to a single fluorophore; (D) ALU clusters and their barycentre (black) are shown.