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. 2017 May 7;18(5):1005. doi: 10.3390/ijms18051005

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mean heterochromatin density around ALU clusters after irradiation with different doses (about 200 ALU clusters were detected per cell, 30 to 40 cells were analysed per dose value). The density distribution for every ALU cluster was determined, and the mean values were computed. The data shows that irradiation influences the heterochromatin density around ALU clusters. A clear difference between irradiated and non-irradiated cells is visible, indicating a de-compaction. However, the underlying mechanism seems to be independent of the dose, since no considerable differences are visible between the irradiations (0.1 to 2 Gy).