Table 3.
Adjusted analyses for the NO2-cytokine relationship mediated by post-bronchodilator airflow obstruction 1,2.
| Mediation Analysis Effect | Post-BD Airflow Obstruction as the Mediator between NO2 and Serum Pro-Inflammatory Cytokines (Mean (95% CI)) | ||
|---|---|---|---|
| IL-6 | IL-8 | TNF-α | |
| Indirect Effect | 0.0003 (−0.007, 0.008) | 0.003 (−0.02, 0.01) | −0.001 (−0.004, 0.01) |
| Direct Effect | 0.175 (0.04, 0.30) | 0.090 (−0.03, 0.20) | 0.056 (0.003, 0.11) |
| Total Effect | 0.175 (0.04, 0.30) | 0.092 (−0.04, 0.20) | 0.055 (0.001, 0.11) |
| % of Total Effect mediated | 0.17% | 2.92% | 1.56% |
Definition of abbreviations: AO, airflow obstruction; BD, bronchodilator; CI, confidence interval; NO2, nitrogen dioxide. 1 NO2 exposure included as a categorical variable by definition (≤5.8, >5.8 ppb). 2 Adjustment included body mass index, smoking status, pack-year group, sex, highest education, sampling weights, blood collection time and delivery, season and batch.