SOX2 |
SOX2 is a transcriptional activator that identity neural stem cells. In addition to regulating the progression of neurogenesis, this group of activators is also active in post-mitotic neurons. |
WNT3A |
WNTs are a family of lipid-modified secreted glycoproteins involved on stem cell niches. |
END |
(endoglin or CD 105): human endoglin is an RGD-containing transmembrane glycoprotein identified in vascular endothelial cells. |
CD44 |
A ubiquitous multistructural and multifunctional cell surface adhesion molecule involved in cell-cell and cell-matrix interactions. CD44 also participates in the uptake and intracellular degradation of HA, it is present in mesenchymal stem cells. |
FUT4 |
A myeloid α1,3-fucosyltransferase responsible for the fucosylation of adhesive interactions between selectins and their ligands, and it plays an essential role in hematopoietic cell lines. |
COLL1 |
Collagen type I is present in the extracellular matrix and it is produced by mesenchymal stem cells. |
CTNNB1 |
The β-catenin gene is involved in WNT signaling. The WNT factor family plays numerous roles in embryonic development and stem cell biology. WNT signaling is transduced by the FZD family of receptors. |
hbEGF |
Heparin-binding epidermal growth factor-like growth factor: a member of the EGF family of growth factors, which interact with the EGF receptor to exert mitogenic activity in various cell types. Recent studies indicate that HB-EGF contributes to neuronal survival and the proliferation of glial/stem cells. |
KRTLG |
Also know as Stem Cell Factor (SCF): a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Signaling from c-Kit is crucial for normal hematopoiesis, pigmentation, fertility, gut motility, and some aspects of the nervous system. |
MMP2 |
Matrix metalloproteinases 2: a protein involved in the migration of hematopoietic stem cells through the blood and across the endothelial vasculature to different organs and to their bone marrow (BM) niches, or, in other words, during the homing process. |
VIM |
Vimentin: a type III intermediate filament protein that is expressed in mesenchymal cells. |