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APC/C-Cdh1 regulates synaptic plasticity. The ubiquitin ligase APC/C-Cdh1 degrades FMRP and GluR1, thereby regulating LTD and homeostatic plasticity. To date, no direct APC/C targets have been identified that regulate LTP (potential unknown substrates indicated by ‘?’), but strong evidence suggests direct or indirect regulation of LTP the protein complex.
