Table 6.

Studies of inhaled tobramycin in NCFB patients with P. aeruginosa present in sputum.

Study/Year	Preparation	Dose/Frequency	Duration	Patient Population	Key Outcomes after Treatment
Barker 2000 [95]	TSI	300 mg/BID	28 days	n = 74	Decrease in bacterial load
Scheinberg 2005 [96]	TSI	300 mg/BID	14 days on, 14 days off (3 cycles)	n = 41	Improvements in respiratory symptoms
Drobnic 2005 [97]	TSI	300 mg/BID	6 months	n = 30	Improvement in the number of admissions and days of admission to the hospital
Bilton 2006 [98]	Oral ciprofloxacin or oral ciprofloxacin + TSI	750 mg/BID (ciprofloxacin) 300 mg/BID (TSI)	2 weeks	n = 53, with an acute exacerbation	Double therapy resulted in a trend towards greater rates of eradication, but cure rates and relapse rates were similar in both groups

BID, twice a day; TSI, tobramycin solution for inhalation.