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CYP450 fold induction and inhibition in primary human hepatocytes in response to known inducers and inhibitors of CYP3A4, CYP2B6, and CYP1A2, normalized to control. Higher or comparable CYP450 fold induction was observed in 2D compared to 3D. Aside from ticlopidine, where there was no significant inhibition, greater CYP450 fold inhibition was observed in 3D than in 2D. Error bars represent standard error.
