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Effect of DNA-PK inhibitor Nu7026 on 1,2,3,4-diepoxybutane (DEB)-induced cell death in human and hamster cells. Cells were exposed to DEB in the presence or absence of 10 µM Nu7026 and the percent cell death determined as described in the Methods section.
| Cell Line | PDcorr (WT) | PD20 (-FANCD2) | V79 (WT) | V-H4 (-FANCA) | ||||
|---|---|---|---|---|---|---|---|---|
| Nu7026 | - | + | - | + | - | + | - | + |
| Percent cell death (± SEM) | 21 (± 1.4) | 20 (± 7.8) | 40 (± 2.8) | 42 (± 8) | 23 (± 1.4) | 22 (± 1.4) | 42 (± 2.1) | 42 (± 3.5) |
