Table 2.
Clinical features of patients with different SLE onset ages
| Variables | cSLE (n = 225) | aSLE (n = 1759) | t/Z/χ2 | P |
|---|---|---|---|---|
| Initial manifestation | ||||
| Fever | 134 (59.6) | 627 (35.6) | 48.234* | <0.001 |
| Musculoskeletal | 91 (40.4) | 977 (55.5) | 18.297* | <0.001 |
| Mucocutaneous | 149 (66.2) | 941 (53.5) | 13.050* | <0.001 |
| Hemocytopenia | 76 (33.8) | 557 (31.7) | 0.410* | 0.522 |
| Renal | 75 (33.3) | 437 (24.8) | 7.509* | 0.006 |
| Neuropsychiatric | 8 (3.6) | 64 (3.6) | 0.004* | 0.950 |
| Respiratory | 11 (4.9) | 94 (5.3) | 0.082* | 0.774 |
| Clinical manifestation | ||||
| Malar rash | 134 (59.6) | 848 (48.2) | 10.274* | 0.001 |
| Discoid lesions | 11 (4.9) | 97 (5.5) | 0.152* | 0.697 |
| Arthritis | 87 (38.7) | 994 (56.5) | 25.275* | <0.001 |
| Serositis | 25 (11.1) | 295 (16.8) | 4.724* | 0.030 |
| Renal disorder | 112 (49.8) | 833 (47.4) | 0.405* | 0.525 |
| Neurologic disorder | 11 (4.9) | 88 (5.0) | 0.005* | 1.000 |
| ILD | 5 (2.2) | 70 (4.0) | 2.285 | 0.173 |
| PAH | 6 (2.7) | 63 (3.6) | 0.732* | 0.388 |
| Leukocytopenia | 43 (19.1) | 425 (24.2) | 2.823* | 0.093 |
| Thrombocytopenia | 27 (12.0) | 292 (16.6) | 3.129* | 0.077 |
| Hypocomplementemia | 142 (63.1) | 1179 (67.0) | 1.375* | 0.241 |
| SLEDAI | 9.39 ± 6.89 | 9.74 ± 7.07 | −0.709† | 0.478 |
| Autoantibody-positive | ||||
| Anti-dsDNA | 77 (34.2) | 504 (28.7) | 2.988* | 0.084 |
| Anti-Sm | 37 (16.4) | 290 (16.5) | 0.045* | 0.987 |
| Anti-RNP | 19 (8.4) | 156 (8.9) | 0.045* | 0.833 |
| Anti-SSA | 48 (21.3) | 428 (24.3) | 0.984* | 0.321 |
| Anti-SSB | 19 (8.4) | 194 (11.0) | 1.390* | 0.238 |
| APL | 47/112 (42.0) | 344/775 (44.4) | 0.233* | 0.629 |
Values are presented as mean ± SD, n (%) or n/N (%). *χ2 values; †t values. SD: Standard deviation; ILD: Interstitial lung disease; PAH: Pulmonary arterial hypertension; SLEDAI: SLE disease activity index; dsDNA: Double-stranded DNA; Sm: Smith; RNP: Ribonucleoprotein; SSA: Sjögren’s syndrome-related antigen A; SSB: Sjögren’s syndrome-related antigen B; APL: Antiphospholipid antibody; cSLE: Childhood-onset SLE; aSLE: Adult-onset SLE; SLE: Systemic lupus erythematosus.