Table 2B.

CUP-associated differentially expressed mRNAs identified from human placentas.

CUP	Comparison _regulation	P value	FC	Gene accession	Gene symbol	Unigene	Protein accession	Protein
Collagen	A+C vs. B+D_up	5.7E–18	2.76	NM_031361	COL4A3BP	Hs.270437	NP_112729	Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
	A+C vs. B+D_up	4.2E–05	3.81	NM_000494	COL17A1	Hs.117938	NP_000485	Collagen, type XVII, alpha 1
	C vs. A _up	4.3E–17	3.51	NM_031361	COL4A3BP	Hs.270437	NP_112729	Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
	C vs. A _up	9.6E–09	6.78	NM_000494	COL17A1	Hs.117938	NP_000485	Collagen, type XVII, alpha 1
Ubiquitin Enz.	A+B vs. C+D_up	1.2E–19	2.03	NM_001144072	UBAC2	Hs.508545	NP_808882	UBA domain containing 2
	A+B vs. C+D_up	1.0E–07	2.37	NM_181892	UBE2D3	Hs.518773	NP_871622	Ubiquitin-conjugating enzyme E2D 3 (homolog, yeast)
	A+B vs. C+D_up	1.8E–19	2.73	NM_006357	UBE2E3	Hs.470804	NP_872619	Ubiquitin-conjugating enzyme E2E 3 (homolog, yeast)
	A+B vs. C+D_up	7.8E–19	2.68	NM_153477	UXT	Hs.172791	NP_705582	Ubiquitously-expressed transcript
	A+B vs. C+D_up	1.7E–10	2.11	NM_001110303	USP20	Hs.5452	NP_006667	Ubiquitin specific peptidase 20
	A+B vs. C+D_up	1.8E–19	2.46	NM_001145073	USP27X	Hs.143587	NP_001138545	Ubiquitin specific peptidase 27, X-linked
	A+B vs. C+D_up	2.4E–15	2.18	NM_001098536	USP5	Hs.631661	NP_003472	Ubiquitin specific peptidase 5 (isopeptidase T)
	A+B vs. C+D_up	1.5E–18	2.14	NM_203494	USP50	Hs.677758	NP_987090	Ubiquitin specific peptidase 50
	A+B vs. C+D_down	8.3E–18	2.77	NM_016525	UBAP1	Hs.268963	NP_057609	Ubiquitin associated protein 1
	A+B vs. C+D_down	3.5E–19	2.72	NM_018449	UBAP2	Hs.493739	NP_060919	Ubiquitin associated protein 2
	A+B vs. C+D_down	1.2E–17	2.29	NM_001001992	USP16	Hs.99819	NP_006438	Ubiquitin specific peptidase 16
	A+B vs. C+D_down	3.9E–17	2.54	NM_015306	USP24	Hs.477009	NP_056121	Ubiquitin specific peptidase 24
	A+B vs. C+D_down	3.6E–15	2.01	NM_004223	UBE2L6	Hs.425777	NP_937826	Ubiquitin-conjugating enzyme E2L 6
	A+B vs. C+D_down	1.1E–19	2.39	NM_001145335	UBE2Q2	Hs.23033	NP_775740	Ubiquitin-conjugating enzyme E2Q family member 2
	A+B vs. C+D_down	5.4E–17	2.67	NM_173469	UBE2Q2	Hs.23033	NP_775740	Ubiquitin-conjugating enzyme E2Q family member 2
	A+B vs. C+D_down	1.7E–11	2.10	NM_023079	UBE2Z	Hs.514297	NP_075567	Ubiquitin-conjugating enzyme E2Z
	A+B vs. C+D_down	2.5E–17	2.47	NM_007106	UBL3	Hs.145575	NP_009037	Ubiquitin-like 3
	C vs. A _down	2.1E–10	2.07	NM_001144072	UBAC2	Hs.508545	NP_808882	UBA domain containing 2
	C vs. A _down	1.9E–06	2.51	NM_001110303	USP20	Hs.5452	NP_006667	Ubiquitin specific peptidase 20
	C vs. A _down	2.0E–09	2.27	NM_001145073	USP27X	Hs.143587	NP_001138545	Ubiquitin specific peptidase 27, X-linked
	C vs. A _down	1.2E–08	2.09	NM_203494	USP50	Hs.677758	NP_987090	Ubiquitin specific peptidase 50
	C vs. A _down	4.1E–03	2.07	NM_181892	UBE2D3	Hs.518773	NP_871622	Ubiquitin-conjugating enzyme E2D 3 (homolog, yeast)
	C vs. A _down	5.5E–09	2.70	NM_006357	UBE2E3	Hs.470804	NP_872619	Ubiquitin-conjugating enzyme E2E 3 (homolog, yeast)
	C vs. A _down	1.7E–13	2.18	NM_194259	UBE2I	Hs.302903	NP_919237	Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
	C vs. A _down	5.5E–08	2.15	NM_153477	UXT	Hs.172791	NP_705582	Ubiquitously-expressed transcript
	C vs. A _up	1.3E–11	3.08	NM_016525	UBAP1	Hs.268963	NP_057609	Ubiquitin associated protein 1
	C vs. A _up	8.8E–08	2.29	NM_018449	UBAP2	Hs.493739	NP_060919	Ubiquitin associated protein 2
	C vs. A _up	2.5E–10	2.03	NM_015902	UBR5	Hs.492445	NP_056986	Ubiquitin protein ligase E3 component n-recognin 5
	C vs. A _up	2.7E–07	2.27	NM_175748	UBR7	Hs.728932	NP_786924	Ubiquitin protein ligase E3 component n-recognin 7 (putative)
	C vs. A _up	8.4E–14	2.88	NM_001001992	USP16	Hs.99819	NP_006438	Ubiquitin specific peptidase 16
	C vs. A _up	2.6E–11	2.33	NM_017414	USP18	Hs.38260	NP_059110	Ubiquitin specific peptidase 18
	C vs. A _up	2.4E–08	2.18	NM_015306	USP24	Hs.477009	NP_056121	Ubiquitin specific peptidase 24
	C vs. A _up	4.8E–10	2.45	NM_001145335	UBE2Q2	Hs.23033	NP_775740	Ubiquitin-conjugating enzyme E2Q family member 2
	C vs. A _up	1.4E–11	2.47	NM_173469	UBE2Q2	Hs.23033	NP_775740	Ubiquitin-conjugating enzyme E2Q family member 2
	C vs. A _up	8.1E–08	2.31	NM_023079	UBE2Z	Hs.514297	NP_075567	Ubiquitin-conjugating enzyme E2Z
	C vs. A _up	2.5E–12	2.85	NM_007106	UBL3	Hs.145575	NP_009037	Ubiquitin-like 3
	A vs. B _up	2.4E–05	2.60	NM_199144	UBE2V1	Hs.727525	NP_954595	Ubiquitin-conjugating enzyme E2 variant 1
	A vs. B _down	6.5E–13	2.03	NM_181762	UBE2A	Hs.379466	NP_861442	Ubiquitin-conjugating enzyme E2A (RAD6 homolog)
Protease	A+B vs. C+D_up	2.4E–07	2.09	NM_152891	PRSS33	Hs.280658	NP_690851	Protease, serine, 33
	A+B vs. C+D_down	2.6E–20	2.18	NM_148919	PSMB8	Hs.180062	NP_683720	Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
	C vs. A_down	6.1E–06	2.20	NM_001080492	PRSS54	Hs.411239	NP_001073961	Protease, serine, 54
	C vs. A_up	1.3E–12	2.27	NM_148919	PSMB8	Hs.180062	NP_683720	Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
	A vs. B_up	4.1E–05	3.23	NM_002804	PSMC3	Hs.250758	NP_002795	Proteasome (prosome, macropain) 26S subunit, ATPase, 3

A, sPTL; B, FTB; C, PPROM; D, PROM; FC, fold change; Enz, enzyme.