Table 2.

Univariate and multivariate analyses of prognostic factors for overall survival and progression-free survival

Variable	Univariate	Multivariate
	P value	HR (95% CI)	P Value
Overall survival
Age (>65 vs. ≤65)	<0.001	1.615 (1.116–2.337)	0.011
Gender (male vs. female)	0.264
Histology type (NUC vs. UC)	0.363
Pathological grade (3 vs. 2)	<0.001
pT (pT2 or greater vs. pT1)	<0.001	2.796 (1.700–4.598)	<0.001
pN status (positive vs. negative)	<0.001	1.682 (1.141–2.480)	0.009
Smoking history	0.937
Hypertension	0.480
Diabetes Mellitus	0.534
Heart disease	0.018
Cerebrovascular disease	0.032
ASA grade (3&4 vs. 1&2)	<0.001	1.641 (1.113–2.418)	0.012
Hypoalbuminemia	<0.001
Anemia	<0.001
Postoperative complications	0.003	1.607 (1.076–2.400)	0.020
PNI (low vs. high)	<0.001	1.668 (1.147–2.425)	0.007
PLR (high vs. low)	<0.001
NLR (high vs. low)	<0.001	1.416 (1.094–2.016)	0.014
LMR (low vs. high)	<0.001
Progression-free survival
Age (>65 vs. ≤65)	<0.001
Gender (male vs. female)	0.304
Histology type (NUC vs. UC)	0.683
Pathological grade (3 vs. 2)	<0.001
pT (pT2 or greater vs. pT1)	<0.001	2.560 (1.677–3.906)	<0.001
pN status (positive vs. negative)	<0.001	1.871 (1.306–2.680)	0.001
Smoking history	0.952
Hypertension	0.604
Diabetes Mellitus	0.681
Heart disease	0.012
Cerebrovascular disease	0.033
ASA grade (3&4 vs. 1&2)	<0.001	1.561 (1.086–2.243)	0.016
Hypoalbuminemia	<0.001
Anemia	<0.001
Postoperative complications	0.004
PNI (low vs. high)	<0.001	1.680 (1.092–2.005)	0.011
PLR (high vs. low)	<0.001
NLR (high vs. low)	<0.001	1.550 (1.140–2.388)	0.008
LMR (low vs. high)	<0.001

UC urothelial carcinoma, NUC non-urothelial carcinoma, ASA American Society of Anesthesiologists, PNI prognostic nutritional index, NLR neutrophil-lymphocyte ratio, PLR platelet-lymphocyte ratio, LMR lymphocyte-monocyte ratio

Significant values are in bold