Table 1. The genetic and genomic locations of markers of P. c. chabaudi strain CB affected by CB-specific immune selection in mice.
| Chromosomal mapping
|
||||
|---|---|---|---|---|
|
P. chabaudi*
|
P. falciparum
|
|||
| Name of marker | Cl in CB-immune mice, % | Chromosome no. | Chromosome no. | Approximate position, kb |
| CBCA01CT | 10 | ND | 1 | pf1-0288 |
| CBGA01AG | 32 | ND | 2 | pf2-0310 |
| CBCA07AT | 18 | ND | 5 | pf5-0285 |
| CBGT02AC | 36 | ND | 5 | pf5-1013 |
| CBAC03AT | 46 | 8 | ND | ND |
| CBAC01AG | 40 | 8 | 9 | pf9-0742 |
| CBAT02TA | 39 | ND | 9 | pf9-0910 |
| CBGT01GT | 28 | ND | 9 | pf9-1007 |
| CBAT01AG | 30 | ND | 9 | pf9-1029 |
| CBTT04AT | 13 | 8 | 9 | pf9-1040 |
| CBTC02TT | 18 | ND | 9 | pf9-1164 |
| CBGT06AT | 8 | ND | 9 | pf9-1168 |
| CB msp1† | 1 | 8 | 9 | pf9-1203 |
| CBAG05AT | 12 | 8 | 9 | pf9-1263 |
| CBAT01TA | 16 | 8 | ND | ND |
| CBAG02AG | 26 | 8 | 9 | pf9-1372 |
| CBCT01TC | 44 | 11 | ND | ND |
| CBAC01GA | 34 | ND | 12 | pf12-1490 |
| CBAC04AT | 41 | 13 | ND | ND |
| CBTA01GA | 45 | ND | 14 | pf14-1621 |
| CBTT01CA | 37 | ND | 14 | pf14-1892 |
| CBTC05AG | 45 | ND | 14 | pf14-2037 |
| CBTT01TG | 28 | g6 | ND | ND |
| CBTT06TT | 37 | g14 | ND | ND |
CB markers that were strongly reduced (i.e., with a Cl of <50%) in the uncloned progeny of the genetic cross between P. c. chabaudi AS-PYR1 and CB after selection in CB immunized mice are shown. Physical distances in kilobase pairs for P. falciparum are from the P. falciparum genome database. Genetic distances for P. c. chabaudi markers are shown in Figs. 2 and 3 in centimorgans. The largest group of linked markers under selection (in bold) form the selection valley around the msp1 locus (underlined because it is not an AFLP marker) on chromosome 8 of P. c. chabaudi and chromosome 9 of P. falciparum (see also Fig. 3). ND, not determined.
*
These markers were genetically mapped onto their chromosomes.
†
Measured by RTQ-PCR assay.