Fig. 6.

Comparison between reliable two-point Φ values (filled squares) of mutants with a TS similar to wild type, and the structure of wild-type TS as measured by S_xΦ values (open symbols). The structural Φ values are the ratio between the number of contacts formed in the TS and native state. S_NatΦ takes into account only native contacts, whereas S_AllΦ includes native and nonnative contacts. The two-point Φ values tend to overestimate the degree of nativeness of the TS (measured by S_NatΦ) because of the presence of specific nonnative interactions.