Table 1.
Effects of different pH and surfactants on the solubility of albendazole (n = 3).
| Formulation | Solubility (μg/mL) | |
|---|---|---|
| Buffer pH | pH 2 | 23.54 ± 2.94 |
| pH 4 | 8.63 ± 0.64 | |
| pH 6 | 8.04 ± 0.26 | |
| pH 8 | 1.33 ± 0.13 | |
| pH 10 | 3.70 ± 0.05 | |
| Surfactant * | Tween 20 | 42.03 ± 9.49 |
| Tween 60 | 8.97 ± 1.70 | |
| Tween 80 | 23.58 ± 0.94 | |
| Span 80 | 4.50 ± 1.11 | |
| Arlacel 80 | 14.07 ± 3.50 | |
| α-cyclodextrin | 3.30 ± 0.07 | |
| β-cyclodextrin | 12.25 ± 0.22 | |
| γ-cyclodextrin | 1.33 ± 0.00 | |
| Poloxamer 188 | 2.83 ± 0.44 | |
| Poloxamer 407 | 2.99 ± 0.75 | |
| Cremophor RH 40 | 24.48 ± 8.07 | |
| Eudragit L-100 | 2.48 ± 0.44 | |
Note: * Concentration of surfactants was applied as 1% (v/v or w/v).