Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) total scores in patients with breast cancer and controls prechemotherapy, postchemotherapy, and 6 months after chemotherapy. Smaller values imply greater cognitive deficit. Patients reported significant decline, that is, greater perceived difficulty, in FACT-Cog score after chemotherapy and 6 months after chemotherapy. Assessment 1 is prechemotherapy (0 months), assessment 2 is postchemotherapy (4.8 months), and assessment 3 is 6 months after assessment 2 (11.5 months). Controls are assessed at the same time intervals as patients. Scores represent mean and 95% CIs, not adjusted for multiplicity.