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. Author manuscript; available in PMC: 2017 Jun 2.
Published in final edited form as: Cell Rep. 2017 Apr 11;19(2):335–350. doi: 10.1016/j.celrep.2017.03.052

Figure 3. RNA-seq of adult Chd8+/− brain regions shows globally dysregulated genes and pathways.

Figure 3

(A) Table of the top 10 upregulated (top) and downregulated (bottom) differentially expressed genes. Differential expression analysis using DEseq2 was performed on a TPM expression matrix from RNA sequencing libraries generated from different brain regions when comparing 10-week old male Chd8+/− mice and wild-type littermates. Also see Figure S4.

(B) Table of differentially expressed ASD-associated genes in different brain regions when comparing 10-week old male Chd8+/− mice and wild-type littermates. Genes bound by CHD8 are denoted with Y.

(C) Enriched gene sets in Chd8+/− mice. Gene set enrichment analysis was performed on RNA sequencing libraries generated from different brain regions when comparing 10-week old male Chd8+/− mice and wild-type littermates. Table of enriched gene sets with FDR below 8%.