Fig 1.

Kaplan-Meier plots of relapse-free survival for residual cancer burden (RCB) categories within the yp-stage categories from pooled analysis of the patients with residual disease from the five cohorts (N = 895): (A) yp-stage I (n = 218); (B) yp-stage II (n = 418); and (C) yp-stage III (n = 259). This analysis excluded 12 patients who did not undergo surgery immediately after neoadjuvant treatment (as a result of progression). Note that the original development cohort (cohort 1, Table 1) was included in these analyses. The length of each x-axis is proportional to the duration of follow-up of survivors, truncated when < 10% of the smallest group remained at risk. Response categories are shown as RCB-I (gold), RCB-II (gray), and RCB-III (red).