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Primary sequence, hydrophobicity profile, and predicted features of the syncytin-A and -B envelopes. The SU and TM moieties of the envelopes are delineated, with the canonical furin cleavage site (R/K-N-R/K-R) between the two subunits and the CWVC domain involved in SU–TM interaction underlined; the hydrophobic fusion peptide and TM domains are shaded in light gray, and the putative immunosuppressive domain (ISU) in dark gray.
