Fig 2.

Association of disease status at first restaging with (A) CMI and (B) CTCs across three time points. The length of the box is the interquartile range and represents the middle 50% of the data. The horizontal line inside the box shows the median. The lower and upper edges of the box represent the 25th and 75th percentiles, respectively. The vertical dashed lines extend from the box to the upper and lower 1.5 interquartile values from the upper and lower edges. Jonckheere-Terpstra test for trend in change from baseline among ordered disease status at first restaging. *Significant difference (P < .001) at the given time point compared with baseline using Wilcoxon signed rank test. Natural log transformed CMI and CTC data were graphed and the y-axes were formatted with back-transformation values. CMI, cumulative methylation index; CTCs, circulating tumor cells; PD, progressive disease; PR/CR, partial response/complete response; SD, stable disease.