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. 2015 Jul 24;8(8):4733–4750. doi: 10.3390/ma8084733

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Repair of a critical defect on the rabbit radius by using mineralized collagen: (a) After surgery (the defect is noted by the arrow). (b) Implant at 12 weeks, double cortical bone connected completely (the regenerated bone tissue is noted by the arrow). (c) Implant at eight weeks, decalcified histology hematoxylin-eosin staining. (d) Implant at 12 weeks, decalcified histology hematoxylin-eosin staining (compared to eight weeks, more new trabeculae replace the composite). Reprinted with permission from reference [49]. Copyright 2004 John Wiley and Sons.