Fig. 4.

Polypeptide segment 165–172 in the energy-minimized NMR structures of bPrP, hPrP, mPrP, shPrP, and ePrP and in mPrP[N174T] and mPrP[S170N,N174T]. The backbone is represented by a spline function through the C^α positions. The radius of the cylindrical rods is proportional to the mean backbone displacement per residue, as evaluated after superposition for best fit of the atoms N, C^α, and C′ of the residues 166–172 in the 20 energy-minimized conformers used to represent the NMR structures. For the amino acid sequences, see Fig. 1B.