Excess risk of an acute coronary event (ACE) depending on the mean V5 of the left ventricle (LV-V5) in volume percentage calculated per age category and risk factor: (A) no cardiac risk factors, (B) diabetes, (C) hypertension, and (D) ischemic cardiac event. For example, a patient age 70 years with an LV-V5 of 50% and no cardiac risk factors has an excess risk of 2.52% of developing an ACE within 9 years after radiotherapy. If the same patient had a history of ischemic heart disease, with a similar value for LV-V5, the excess risk would increase to 8.42%.