FIG. 5.

Remote ischemic preconditioning (rIPC). The picture illustrates the protective effects of rIPC maneuver, induced by four cycles of 5 min of occlusion, followed by 5 min of reperfusion, inducing a repetitive increase in shear stress accompanied by mechanotransduction, including eNOS activation and NO release. The blue arrows indicate transduction of protective signals from the vessel endothelium of the brachial arteries to the brain, lung, heart, liver, kidney, and other vessels. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars