Figure 5.

LRP5–Tie2 signaling mediates compensatory lung growth after PNX. (A) Graph showing the ratio of weight of the lung cardiac lobe to mouse body weight 7 days after PNX with or without treatment with PRP extract in wild-type C57BL/6 mice or Lrp5^−/− mice (n = 7; mean ± SEM). *P < 0.05. (B) H&E–stained mouse right lung cardiac lobe 7 days after PNX with or without treatment with PRP extract in Lrp5^−/− mice. Scale bar, 50 μm. Graph showing the quantification of alveolar size (MLI, left) and the alveolar number (right) (n = 7; mean ± SEM). *P < 0.05.